Biosafety and biosecurity are disciplines that have developed tools to prevent health hazards for humans, animals and plants. In TM6, the theoretical principles of biosecurity and biosafety are introduced, followed by a discussion on their application within a One Health approach, supported by concrete case studies. Participants will visit the Spiez Laboratory, which specialises in highly infectious diseases and engage in real-life, hands-on exercises. The module is taught in collaboration with the Swiss Biosafety Network (SBNet).